Each cell uses particular schemes of molecular interaction, which physiologists call inter-cellular signaling pathways.
A signaling pathway is a chain of sequential events of interaction between certain molecules which make the cell respond to stimulation.

The team of experts from MIPT and other Russian and British organizations suggested comparing peculiarities of signaling pathways activation in young and ageing cells.
This information is then expanded with the available data on the impact of various substances on signaling pathways.

The new algorithm helps to predict the type of change in the profile of intracellular molecular interaction which will occur in response to drugs, researchers said.

Scientists point out that their algorithm can be used in rapid and inexpensive search for drugs which can minimize the difference between the cells of young and elderly patients.

This means that it will be possible to speed up the search for longevity drugs and decrease its cost, researchers said.
What is more, this will be achieved not by simply fighting some particular diseases, but by a complex influence on the mechanisms of ageing, they said.

The research was published in the journal Frontiers in Genetics magazine.


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