The husband of late former premier Benazir Bhutto, Zardari had a controversial term, but was able to keep democracy on track through a series of understandings and alliances with the country's main political parties.
Zardari, the de facto chief of the Pakistan People's Party, faced a strong and assertive judiciary that pursued against him over multi-million-dollar graft cases in Switzerland.
One casualty of the struggle was former premier Yousuf Raza Gilani, who lost his job when he was disqualified by the Supreme Court for refusing to implement its order to ask Swiss authorities to reopen the cases.
As Zardari prepares to step down, speculation is rife on what he will do in future.
Some say he is likely to spend his time abroad while others close to him say he will remain in Pakistan and work to strengthen the PPP, which is now the main Opposition party.
The PPP faced a crushing defeat in the May 11 General Election but emerged as the second largest party after the ruling PML-N.
Zardari’s son Bilawal, who is the chairman of the PPP, can become fit for Parliamentary affairs only after he turns 25 in September. Bilawal stayed away from the PPP's lacklustre poll campaign because of ‘security threats.’
After Zardari steps down, the new President will be sworn in on Monday. Replacing Zardari would be Mamnoon Hussain, who beat former judge Wajihuddin Ahmad of the Pakistan Tehrik-e-Insaf in a one-side presidential poll.