Lead researcher Sam Berkovic, Director of the Epilepsy Research Centre at the University of Melbourne and Melbourne's Austin Hospital said that while providing a pathway to treating epilepsy the research provides answers to patients and families who previously had little or no idea where epilepsy had come from.
    
"Parents often have a belief that they've done something wrong that caused this disease," Berkovic said.
    
"Not knowing why, has been one of the most frustrating things. We've never really had the answer. Now we do. This also stops the need for further searching and refines the treatments," he said.
    
A key aspect of the research has been the ability to sequence the entire human genome, Berkovic said adding "Until now we've had these complex patients and we didn't know what was going on. Now all the genes are known and the jigsaw can be completed."
    
By using the latest genetic techniques to sequence and analyze DNA of 4,000 epilepsy patients and their relatives, the study known called Epi4Ks shared DNA sequences and patient information among dozens of research institutions. The researchers compared the exomes, or the complete sets of genes, of 264 children with the sequences of their parents who do not have epilepsy.
    
Differences in the sequences of parents and children were analyzed to identify potential disease-causing mutations. The study's joint leader Dr David Goldstein, the Director of the Human Genome Variation Centre at Duke University Medical Centre in the US, said that his team's work identified an unusually large number of disease-causing mutations and provided a wealth of new information.
    
"We are now headed toward a future where we can find out why people have this disease and tailor the treatment of it. It establishes a clear path to the genetic explanation of epilepsy," Dr Goldstein said.

(Agencies)

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