The Australians, with man-of-the-match George Bailey smashing an unbeaten 49 off 20 balls, scored 195 for six after winning the toss in Sydney. (JPN/Agencies)
The home side then dismissed the psychologically-scarred tourists for 111 in the 18th over to sweep the series.
It marked the end of a disastrous 103-day tour for England, who lost the Ashes Tests 5-0 and the one-day international series 4-1, meaning Australia won 12-1 across the three formats.
In between the losses, the international careers of spinner Graeme Swann and coach Andy Flower have been ended.
Skipper Bailey clubbed 26 runs off the last over to steer Australia to their insurmountable total after winning the toss at Sydney's Olympic stadium.
The Aussie skipper smacked 4-6-6-4-4-2 off Jade Dernbach's last over of the innings. In all Australia hit 13 sixes in their innings.
Bailey smashed a total of three sixes and four fours in an unbroken seventh-wicket stand of 56 with wicketkeeper Matthew Wade (19 off 10 balls).
Bailey said Australia's selectors had some welcome headaches to solve ahead of the World T20.
"It was a challenge we threw out to the group... there would be spots up for grabs," he said.
"Guys needed to commit to how the team wanted to play and I can't fault any of them,” Bailey said.
"It's been very, very pleasing and we've finished it off with the most complete performance, which is great,” he said.
The Australians, with man-of-the-match George Bailey smashing an unbeaten 49 off 20 balls, scored 195 for six after winning the toss in Sydney.