Both teams will start what promises to be a memorable duel at the Etihad Stadium boosted by superb wins on Saturday, with City returning to their best form in beating Chelsea 2-0 in the FA Cup and Barcelona crushing Rayo Vallecano 6-0 in La Liga. (Agencies)
Both were also boosted by the return of important players after injury.
Samir Nasri came on as a second-half substitute for City after missing seven games and scored City's second against Chelsea within minutes of his arrival while Neymar also returned as a substitute in the second half for the Spanish champions to score a stunning goal after four matches out to complete Barca's scoring.
Neymar is likely to be on the bench at the start on Tuesday, which may offer some relief for the home team, who will probably have to raise their already impressive game to even greater heights if they are to knock out the four-times European champions.
City coach Manuel Pellegrini is well aware of what Barca are capable of from his time with Villarreal, Malaga and Real Madrid in Spain, while City's free-ranging midfielder Yaya Toure spent three years at the Nou Camp and won ever major honour with them, including the Champions League in 2009.
In an interview with Champions Magazine, Toure said he expected City to win the first leg to show how far the club have come since the injection of Sheikh Mansour's cash totally transformed them from domestic also-rans to potential European champions.
"Our fans deserve a victory against a big club to show how the club is progressing," he said. "Barcelona are a perfect example, a great club with an exceptional history with players who might currently be the best in the world, like Lionel Messi, Iniesta, Xavi, Pique, Busquets.
"It will be a great match and we really have the desire to show City are on the right track."
City are in uncharted waters as far as the Champions League is concerned, having been knocked out at the group stage in their two previous appearances.
But they are the highest scoring team in this season's competition with 28 goals.
"Our experience from our defeats last year has made us more mature," Youre added.
"We have the players, the manager, but you also need to play against great teams to test your level."
City gave a hint of their growing strength with a 3-2 win away to champions Bayern Munich in the group stage, and they have scored 117 goals in all competitions this season.
Both teams will start what promises to be a memorable duel at the Etihad Stadium boosted by superb wins on Saturday, with City returning to their best form in beating Chelsea 2-0 in the FA Cup and Barcelona crushing Rayo Vallecano 6-0 in La Liga.