Features of the anterior cingulate cortex (part of the brain that plays a role in a wide variety of functions, such as regulating blood pressure and heart rate) structure and connectivity seemed to predict whether a patient would respond to the surgical treatment, the findings showed.

"These results suggest that the variability seen in individual responses to a highly consistent, stereotyped procedure may be due to neuroanatomical variation in the patients," said Garrett Banks from Columbia University, New York.

The dorsal anterior cingulotomy is a surgical procedure to treat OCD and involves causing damage to a region of the brain that is believed to play a role in the neural network that causes OCD."These variations may allow us to predict which patients are most likely to respond to cingulotomy, thereby refining our ability to individualize this treatment for refractory psychiatric disorders," the study added. The study was published online in the journal JAMA Psychiatry.


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