Researchers from the Niels Bohr Institute, University of Copenhagen in Denmark found how the finger-like structures 'filopodia' can extend themselves, contract and bend in dynamic movements.
In many biological processes, cell interaction and communication with their environment are critical to their functioning.
To feel their surroundings, the cells use finger-like structures that are actually tube-like protrusions from the cell membrane, researchers said.
These tubes are called filopodia and they can bring messages back to the cell about both the chemical environment and the physical surroundings.
For example, the cells use the filopodia structures for correct development of the embryo, for growing nerve cells and when cells (like macrophages) need to migrate towards pathogenic bacteria in order to remove them.
The researchers Natascha Leijnse, Lene Oddershede and Poul Martin Bendix studied the physical properties of filopodia using an optical trap, which is a microscope where you can hold onto and influence individual living cells using a highly focused laser.
In order to follow the movements better, the researchers placed a small plastic ball on the tip of the filopodia structure and by performing ultrasensitive force measurements, they could measure the dynamic activity in the individual filopodia.
In addition to the force measurements, the internal 'skeleton' of the filopodia, called actin, which is responsible for the movement of the filopodia, was marked with fluorescent markers in order to monitor the movements in the microscope.

"Furthermore, the study revealed a new mechanism that the filopodia use to move. We observed that the actin inside the filopodia exhibited a marked twisting motion and when it drew back, spiral folds were formed - just like when you twist an elastic band, holding tight to one end and pulling the other," Bendix said.

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