People with CFS or systemic exertion intolerance disease experience extreme fatigue and difficulty concentrating due to headaches and muscle pain.

"We now have evidence confirming what millions of people with this disease already know, that CFS is not psychological," stated lead author Mady Hornig, director of translational research at the Center for Infection and Immunity, Columbia University.

"Our results should accelerate the process of establishing the diagnosis after individuals first fall ill as well as discovery of new treatment strategies focusing on these early blood markers," Hornig added.

The researchers identified distinct immune changes in patients diagnosed with chronic fatigue syndrome, known medically as myalgic encephalomyelitis (ME/CFS).

"This study delivers what has eluded us for so long: unequivocal evidence of immunological dysfunction in ME/CFS and diagnostic biomarkers for disease," senior author W. Ian Lipkin from Columbia University's Mailman School of Public Health noted.

The study appeared in the journal Science Advances.



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