It will be the fourth novel in the crime series following Harvard symbologist Robert Langdon, media reported. (Agencies)
Brown said he was influenced by Italian poet Dante's classic work, 'Inferno,' while researching in Florence.
Set in Italy, the book will see Langdon drawn into a harrowing world centred on one of history's most enduring and mysterious literary masterpieces.
"With this new novel, I am excited to take readers on a journey deep into this mysterious realm...a landscape of codes, symbols, and more than a few secret passageways," Brown said.
The book's title was revealed via posts on social media sites including Twitter and Facebook.
Every time fans mentioned the novel, a piece of a mosaic was unlocked which eventually revealed the name.
The image appears to show The Basilica of Saint Mary of the Flower - otherwise better known as the Duomo - in Florence.
It will be the fourth novel in the crime series following Harvard symbologist Robert Langdon, media reported.