To determine if there is an association between coffee consumption and risk of cutaneous melanoma, Erikka Loftfield from the division of cancer epidemiology and genetics at US National Cancer Institute used data from the NIH-AARP Diet and Health Study.
Information on coffee consumption was obtained from 447,357 non-Hispanic white subjects with a self-administered food frequency questionnaire in 1995/1996, with a median follow up of 10 years.
All subjects included in the analysis were cancer-free at baseline. Overall, the highest coffee intake was inversely associated with a risk of malignant melanoma, with a 20 percent lower risk for those who consumed four cups per day or more.
There was also a trend toward more protection with higher intake, with the protective effect increasing from one cup to four or more. However, the effect was statistically significant for caffeinated but not decaffeinated coffee and only for protection against malignant melanoma but not melanoma in-situ, which may have a different etiology.
The study was published in the Journal of the National Cancer Institute.