The research exposed a thousand molecular changes that occur in our muscles when we exercise, providing the world's first comprehensive exercise blueprint.
"Exercise is the most powerful therapy for many human diseases, including type 2 diabetes, cardiovascular disease and neurological disorders," said David James, Professor at University of Sydney and the head of the research group.
"However, for many people, exercise isn't a viable treatment option. This means it is essential we find ways of developing drugs that mimic the benefits of exercise," said James.
The University of Sydney researchers, in collaboration with researchers from the University of Copenhagen in Denmark, analysed human skeletal muscle biopsies from four untrained,
healthy males following 10 minutes of high intensity exercise.
With this long-term goal in mind, researchers narrowed down the therapeutic possibilities within the blueprint using mathematical and engineering-based analysis.
"Most traditional drugs target individual molecules. With this exercise blueprint we have proven that any drug that mimics exercise will need to target multiple molecules and possibly even pathways, which are a combination of molecules working together. We believe this is the key to unlocking the riddle of drug treatments to mimic exercise," James said.
The study was published in the journal Cell Metabolism.


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