The two sides sit on three points after two games, both having lost to Costa Rica and beaten England. Italy only need to draw due to their superior goal difference. (JPN/Agencies)
The good news for Uruguay is that deadly striker Luis Suarez, who missed the first match because of injury but came back to sink England with two goals, is fit to play.
Uruguay national football team captain Diego Lugano on Monday asked the fans to dream big ahead of the team's upcoming do-or-die match against Italy.
Uruguayans ‘never give up, we're fighters. We're small but we dream of being giants’," Lugano wrote on micro-blogging site Twitter.
England look to salvage pride against Costa Rica
England, which is now out of the tournament, will try to salvage some pride against Costa Rica in Belo Horizonte. However, it is not going to be an easy task as the Central Americans are on a high and aiming to secure the top spot and set themselves up against the Group C runners-up in the last 16.
England coach Roy Hodgson has already made it clear that he would bring in some fresh faces for their final game.
Young star Ross Barkley, who impressed against both Uruguay and Italy after joining the side as substitute, is expected to start against the Costa Ricans whereas left back Leighton Baines is doubtful for the game due to injury.
Southampton wonder kid Luke Shaw, who is linked heavily with a move to Manchester United, is expected to replace Baines for the game against the Central Americans.
Colombia take on Japan
Meanwhile, Group C leaders Colombia, another Latin American side challenging the region's traditional powers, have qualified for the last 16 with six points but will look to clinch top spot when they take on Japan, who have one point, in Cuiaba.
The Japanese could still qualify with a win but Ivory Coast, currently second on three points, are the favourites before they face Greece, who have one point, in Fortaleza. The Group C winners will face the Group D runners-up in the last 16.
Coach Jose Pekerman has claimed that Colombia want to boost their World Cup tally of five goals against Japan and want to finish the group stage with three wins for the first time.
The two sides sit on three points after two games, both having lost to Costa Rica and beaten England. Italy only need to draw due to their superior goal difference.