Daily dose of coffee can check non-alcoholic fatty liver disease by reducing permeability of the gut, the team reported after conducting the research on mice.

They found that a daily dose of coffee (equivalent to six cups of espresso coffee for humans) improved several key markers of the disease in mice who were fed a high-fat diet.

The mice also gained less weight than others fed the same diet without the dose of caffeine.

"Previous studies have confirmed how coffee can reverse the damage of NAFLD but this is the first to demonstrate that it can influence the permeability of the intestine," said Vincenzo Lembo from the University of Napoli, Italy.

The results also show that coffee can reverse NAFLD-related problems such as ballooning degeneration, a form of liver cell degeneration.

The scientists showed how coffee protects against NAFLD by raising levels of a protein called Zonulin (ZO)-1 which lessens the permeability of the gut. Experts believe that increased gut permeability contributes to liver injury and worsens NAFLD. People suffering from NAFLD can develop scarring of the liver - also known as fibrosis - which can progress to a potentially life threatening condition known as cirrhosis.

The results suggest that coffee supplementation could cause variations in the intestinal tight junctions which regulate the permeability of the intestine.

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