A stress fracture is a fatigue-induced fracture of the bone caused by repeated pressure over time.

Unlike normal fractures, stress fractures are the result of accumulated trauma from repeated mechanical usage, such as running or jumping.
The study found that two specific variations within the gene were associated with stress fracture injuries in healthy, exercising individuals.
The precise mechanism by which these variations may influence stress fracture risk is unknown but may include decreased sensitivity of bone to mechanical loading or adverse changes to specific bone cells, researchers said.
Stress fractures are common injuries for athletes and military personnel. The effect of heavy repeated mechanical usage causes an amalgamation of micro-damage in bone.
The findings were published in The Official Journal of the International Purine Club University of Liverpool.

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