Proton pump inhibitors (PPIs) are one of the most commonly prescribed medications in the US and an estimated 25 percent to 70 percent of these prescriptions may have no appropriate indication for use.
Other observational studies have linked PPIs to serious adverse health outcomes.

However, the researchers said that no population-based studies, to their knowledge, have looked at the association between PPI use and the risk of chronic kidney disease (CKD).
At baseline, PPI users in both groups were more likely to have a higher body mass index and take antihypertensive, aspirin or statin medications.
The study was published in the journal JAMA Internal Medicine.


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