For many people preventing weight gain can seem like an uphill struggle but scientists led by the University of Aberdeen in UK have discovered why it may be even harder for women.
Researchers used a mouse model to uncover a sex difference in weight gain driven by differences in physical activity and energy expenditure.
During the study, they were able to transform obese male mice with increased appetite and reduced physical activity into lean, healthy mice. The same transformation did not occur in the female mice.

The findings could have implications for the development of new sex-specific medications to more effectively tackle the obesity epidemic in the future.
"The World Health Organisation (WHO) reports higher rates of obesity in women worldwide, reaching twice the prevalence of men in some parts of the world," said Lora Heisler from University of Aberdeen who led the study carried in collaboration with researchers from the University of Cambridge and University of Michigan.

"We have discovered that the part of the brain that has a significant influence on how we use the calories that we eat is wired differently in males and females," Heisler said.


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