All opinion polls indicates that the former Secretary of State leads other Democratic presidential candidates, but in a warning sign for her, another presidential candidate Vermont Senator Bernie Sanders appears to have been closing the gap and has been gaining popularity across the country.

The three other Democratic presidential candidates sharing the stage in Las Vegas with Clinton and Sanders would be Martin O'Malley, Jim Webb and Lincoln Chafee.

All three of these would get an opportunity to challenge Clinton's formidable campaign. But political analysts say chances are slim.

All eyes would be on Clinton, who has launched a formidable presidential campaign for the second time.

In her first attempt in 2008, Clinton lost to Barack Obama during the Democratic party's primary.

Vice President Joe Biden, may make a last minute announcement to enter the presidential race – which is being highly speculated upon for quite some time.

An impressive performance by Clinton would help her seal the frontrunner position, or else Sanders might further close the lead, experts said ahead of the debate.

"Bigger goals for Clinton include defining her campaign and showing Democratic voters why they should pick her," reports said.

Ahead of her crucial debate, a latest Fox news poll showed that Clinton remains the front-runner among Democratic primary voters (45 percent), with Bernie Sanders (25 percent) and Biden (19 percent) behind her by about 20 percentage points.

That's almost identical to where things stood three weeks ago, the report said.


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