Roach has been ruled out of the second and final Test along with the one-dayers due to a shoulder injury, while Pollard has been rested from the ODIs due to an undisclosed niggle. (Agencies)
West Indies team physiotherapist CJ Clark said Roach's injury is uncommon among cricketers.
"Kemar has not made the expected recovery from the shoulder injury that kept him out of the first Test and he is returning to the Caribbean for ongoing management and subsequent physical rehabilitation," said Clark.
Shannon Gabriel has been selected to replace his fellow fast bowler and is expected to arrive in India in time for consideration for selection in the second Test which opens on Thursday at the Wankhede Stadium here.
The 25-year-old Roach has been the bright spark in the West Indies attack over the last three years in particular.
He has taken 85 wickets at 27.71 runs apiece in 23 Tests and has risen in the ICC Test bowling rankings to become the only West Indian in the Top-20 at 14th.
"We're sad to announce that Kemar has to return home to the Caribbean and will not have an opportunity on this tour, where we felt he could have made a major difference," said West Indies head coach Ottis Gibson.
West Indies trail 0-1 against in the series, following an innings and 51-run defeat inside three days in the first Test that ended on Friday at Eden Gardens here.
West Indies ODI Squad: Dwayne Bravo (capt), Tino Best, Darren Bravo, Johnson Charles, Narsingh Deonarine, Chris Gayle, Jason Holder, Sunil Narine, Veerasammy Permaul, Kieran Powell, Denesh Ramdin, Ravi Rampaul, Darren Sammy, Marlon Samuels, Lendl Simmons.
Roach has been ruled out of the second and final Test along with the one-dayers due to a shoulder injury, while Pollard has been rested from the ODIs due to an undisclosed niggle.