However, Mahesh Bhupathi's men's doubles campaign came to an end after a tight defeat. (Agencies)
Sania first took the court for the women's doubles event and along with Zimbabwean partner Cara Black cruised to a 7-5 6-1 win in the second round against Monica Niculescu from Roumania and Klara Zakopalova of Czech Republic.
Later, playing with first-time Romanian partner Horia Tecau, she won her mixed doubles first round against Hao-Ching Chan of Chinese Taipei and Robert Lindstedt from Sweden.
The sixth seeded Indo-Romanian pair erased a one-set deficit to win 4-6 7-6(3) 10-8.
Veteran Indian star Leander Paes and his Czech partner Radek Stepanek, seeded fifth, recorded a comfortable 6-1 6-4 win over Italian Daniele Bracciali and Alexandr Dolgopolov from Ukraine to move to the pre-quarterfinals of the men's doubles event.
Now Paes and Stepanek will clash with India's Yuki Bhambri and his New Zealand partner Michael Venus, who had shocked 10th seeds Jean-Julien Rojer and Horia Tecau.
Rohan Bopanna also emerged victorious today in both men's doubles and mixed doubles. With seventh seeded Pakistani partner Aisam-Ul-Haq Qureshi, the Indian rallied to beat the British pair of Colin Fleming and Ross Hutchins 4-6 6-3 6-2 in men's doubles second round.
Bopanna then enjoyed success in the mixed doubles as well. He and her Slovakian partner Katarina Srebotnik, seeded second, overwhelmed Raquel Kops-Jones and Treat Huey 6-2 6-3 in the mixed doubles first round.
"Happy to be through to the third round here in Melbourne. Was a tough match today but glad to have pulled it through," Bopanna tweeted after his win.
However, Mahesh Bhupathi and his American partner Rajeev Ram were ousted after a tight 4-6 6-7(7) defeat against second seeded combination of Alexander Peya and Bruno Soares.
In the girls' singles event, India's Snehadevi Reddy lost 4-6 0-6 to Chinese rival Ying Zhang.
Simran Kaur Sethi also crashed out with a 4-6 2-6 defeat against American 14th seed Katrine Steffensen.
In the boys event, Sumit Nagal lost 3-6 3-6 to local favourite Harry Bourchier.
However, Mahesh Bhupathi's men's doubles campaign came to an end after a tight defeat.