The International Atomic Energy Agency hopes to persuade Iran to finally start addressing long-held suspicions it may have researched how to build atomic bombs.
Tehran has rejected the accusations of weaponisation-related work as forged and baseless, while saying it will cooperate with the IAEA to clear up any "ambiguities".
Saturday's meeting comes 10 days before Tehran and world powers, building on a landmark interim deal that took effect last month, start talks on a long-term accord on Iran's nuclear aspirations that would avert the threat of a Middle East war.
A spokesman for Iran's Atomic Energy Organisation said the meeting had been scheduled for one day but might be extended, the ISNA news agency reported on Friday.
The "aim is to answer the IAEA's questions", Behrouz Kamalvandi was quoted as saying by ISNA, without elaborating.
Iran's Press TV English-language state television said in a headline on its website, citing the same official: "Iran ready to answer all IAEA questions."
Diplomats are cautiously optimistic that after Saturday's talks in Tehran the team of senior IAEA inspectors will be able to show at least some progress in gaining Iran's cooperation.
Iran-IAEA relations have improved since last year's election of a relative moderate, Hassan Rouhani, as president of Iran on a platform to ease the country's international isolation.
Under an agreement signed in November, the IAEA has already visited a heavy water production plant and a uranium mine in Iran. However, those first steps did not go to the heart of its investigation and Western diplomats will watch Saturday's meeting closely to see whether the next phase achieves that.



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