"The Secretary would be emphasising the importance and future potential of our economic partnership with India, State Department Spokesperson Jen Psaki said.
"Obviously the discussion would be on everything from continuing to do more economically and technologically, given that United States and India, we believe, can reach greater level of prosperity together than we would achieve alone," she said.
The three-day Vibrant Gujarat Summit will begin on Sunday in Ahmedabad.
"He would also be reiterating throughout the trip, our shared commitment to address the challenge of climate change, promoting clean energy in the future. Prime Minister Modi has a strong track record in this regard," she said, adding that the Obama administration sees this trip as a pivotal point in India-US relationship.
After a brief stopover in Munich to meet the Sultan of Oman, Kerry leading a high-level US delegation is scheduled to arrive in Ahmedabad on Sunday.
Soon after his arrival, he is expected to visit the Gandhi Ashram, meet members of the civil society and visit the Ford plant, which is expected to open shortly. He would address the Vibrant Gujarat Summit and hold a round table with top Indian CEOs.
Kerry is scheduled to meet Prime Minister Modi on Monday and hold another round-table with American CEOs participating in the summit.
Referring to the multi-fold increase in bilateral trade in the last 10 years, which stands now at about USD 100 billion, Psaki said the summit is an opportunity to further the goal that US President Barack Obama and Prime Minister Modi have talked about in terms of increasing trade five-fold to USD 500 billion.