"Granada CF announces that coach Abel Resino has this morning been relieved of his duties," 19th-placed Granada, who are six points from safety, said on their website (www.granadacf.es) on Friday.
"The team's results on recent matchdays prompted this difficult decision."
Resino's replacement will be named later on Friday and Spanish media reported that they were poised to hand former Rayo Vallecano and Sporting Gijon coach Jose Ramon Sandoval the task of preserving their top-flight status.
Resino, who has also coached Atletico Madrid, Levante and Celta Vigo, took over from the sacked Joaquin Caparros in January having helped save Granada from the drop in 2011-12.
The new coach's first game in charge will be on Sunday at Getafe.

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