Messi has not played since injuring his knee at the end of September during which time champions Barca have pulled three points clear of second-placed Real at the top, largely thanks to the form of the Argentina captain's South American compatriots Neymar and Luis Suarez.
"Obviously he won't be at 100 percent in physical terms due to the time he has been out but he is so important that to have him recovered at least gives us some security," said Enrique.
There was more good news for Luis Enrique on the injury front this week when Barca's Croatia midfielder Ivan Rakitic returned to training after a calf injury.
If Messi and Rakitic start, Messi will be reunited with Neymar and Suarez in attack and Rakitic will likely join Andres Iniesta and Sergio Busquets in a three-man midfield.
Luis Enrique said he was not worried about which match officials would take charge of Saturday's game.

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