Shares of Axis Bank, SBI, ICICI Bank, BHEL, RIL and ITC saw moderate to sharp losses, leading to the BSE index falling for the second straight session.
In Asia, barring Japan, country-specific indices in all major markets rose in a relief rally as the Federal Reserve , after a closely watched two-day meeting issued a statement that had removed a pledge to remain "patient" on raising rates, signaling a possible mid-year rate increase.
However, Fed chief Janet Yellen emphasised that while jobs were picking up the economy was more muted than 3 months ago, adding that consumer spending slipped and inflation slowed.
The 30-share Sensex had risen to a day's high of 28,978.74 in early trade and remained in the green for a major part of the session amid a firming global cues.
However, a late sell-off by participants dragged down the Sensex to touch the day's low of 28,411.70 points. It closed with a loss of 152.45 points, or 0.53 per cent, at 28,469.67.

The gauge lost 114.26 points on Wednesday in a volatile trade.
"Despite positive global cues, equity benchmarks concluded the session with a cut. They failed to capitalise the initial push, which was triggered in response to the US Fed's balanced statement on interest rate hike," said Jayant Manglik, President-retail distribution, Religare Securities.
The 50-share NSE Nifty ended with a loss of 51.25 points, or 0.59 percent, to settle at 8,634.65 after touching the day's high of 8,788.20 and a low of 8,614.65.
Sectorwise, the BSE Banking index suffered the most by losing 1.76 percent, followed by Realty (1.50 percent), Capital Goods (1 percent), Oil & Gas (0.68 percent), FMCG (0.64 percent) and Power (0.52 percent).
Meanwhile, Foreign Portfolio Investors (FPIs) sold shares worth a net Rs 457.43 crore on Wednesday, as per provisional data released by the stock exchanges.

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