Fabregas, who was part of the 2010 World Cup winning side, said Spain will go all out for a win. (Agencies)
Spain were thrashed 1-5 by the Netherlands in their opening encounter, which was like a sweet revenge for the Dutch for their loss in the 2010 final.
"Let's go out and give everything to win because it's the only option we have. They will also try to put pressure on us. The match will be hotly contested," Fabregas said.
"We have to take advantage of their weaknesses because it is a game of life or death in which we better win, because if we do not, we go home," he added.
Fabregas warned not to write off Spain, who are also the European champions.
"Don't write off this bunch of Spanish players. They cannot be considered dead and we will try until the last minute," said Fabregas, who recently moved to Chelsea from Barcelona.
"This team has the courage and the character to stand up and come forward. This is one of the most difficult times we are experiencing, and I trust this group," said Fabregas.
Spain are currently at the bottom of Group B with Australia. The Netherlands leads Group B with three points, followed by Chile also with the same points.
Fabregas, who was part of the 2010 World Cup winning side, said Spain will go all out for a win.