Testosterone is a key male sex hormone that helps maintain sex drive, sperm production and bone health. Over time, low testosterone may contribute to an increase in body fat, loss of body hair and muscle bulk.

"When we reviewed the existing research into testosterone and cardiovascular disease, a growing body of evidence suggested a modest connection between the two," said the study's lead author, Johannes Ruige, of Ghent University Hospital in Belgium.

"A specific pathogenesis did not come forward, but perhaps less frequently investigated events may play a role, such as thrombosis where a blood clot develops in the circulatory system or arrhythmia, where there is a problem with the heart beat or rate.

"Based on current findings, though, we cannot rule out that low testosterone and heart disease both result from poor overall health," Ruige said.

Treating low testosterone with replacement therapy did not have any beneficial effect on cardiovascular health, Ruige said.

The clinical review examined findings from studies on cardiovascular disease and testosterone published between 1970 and 2013.

Although the studies suggested some sort of relationship, existing research found little evidence of a connection between low testosterone and artherosclerosis, the hardening and narrowing of arteries that can cause heart attacks and strokes.

The reviewed studies also found no relationship between testosterone levels and heart attacks.

Many of the studies had cross-sectional designs that do not provide information about causality, but the review also looked at 19 prospective observational studies that can provide additional information about whether one condition causes another.

Because these studies did not completely rule out some potential preceding causes of both low testosterone and cardiovascular disease, additional research is needed to confirm the relationship between the two conditions, Ruige said.

The study will be published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

(Agencies)           

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