Back to his best after returning from a two-month injury layoff in early January, Messi struck twice in Barca's 6-0 thrashing of Rayo Vallecano at the Nou Camp to take his total in Spain's top flight to 228 goals from 263 matches, one more than Real Madrid great Di Stefano managed in 329 games.
Still only 26, Messi climbed above his Argentine compatriot to joint third on the all-time list behind record marksman Telmo Zarra (251) and Hugo Sanchez (234) and level with Raul.
"I would like to think that Messi has still not completely recovered (from his injury)," Barca coach Gerardo Martino told a news conference.
"If he wants to, he will break all the records that he likes," added the Argentine, who hails from Messi's home town of Rosario.
Barcelona, who play their Champions League last 16, first leg match at Manchester City on Tuesday, and Atletico, who visit AC Milan in the competition on Wednesday, have 60 points from 24 matches, ahead of Real who play at Getafe on Sunday.
Atletico's Raul Garcia and Diego Costa struck early to set up a 3-0 win over visitors Real Valladolid, while Villarreal's match at home to Celta Vigo was suspended for about half an hour when what appeared to be a teargas canister was thrown on to the pitch with about three minutes remaining.
Celta were leading 1-0 and after play restarted Nolito made it 2-0 with a free kick in the 90th minute meaning Villarreal missed a chance to close to within a point of fourth-placed Athletic Bilbao.


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