Paris: Defending French Open champions Rafael Nadal and Francesca Schiavone were given first-round matches in Friday's draw against Americans who own a combined two career match wins at Roland Garros.

The top-ranked Nadal's bid to tie Bjorn Borg's record of six titles at the clay-court Grand Slam tournament will begin against John Isner. He's a 6-foot-9 American with a big serve who is ranked 39th and best known for winning the longest match in tennis history, 70-68 in the fifth set at Wimbledon last year.

"He's one of these players that you prefer not to have in the first round," Nadal said. "His style of game is dangerous. His serve is unbelievable."

Play begins Sunday at the French Open, where Nadal is 38-1. Isner is 2-2.

Schiavone, the first Italian woman to win a Grand Slam tournament, is seeded fifth this year and will start off against 89th-ranked Melanie Oudin, a surprise U.S. Open quarterfinalist in 2009 but just 6-16 this season. She's 0-1 at Roland Garros, having lost in the first round a year ago in her tournament debut.

Both Isner and Oudin are from Georgia.

Second-ranked Novak Djokovic, who has won all 37 matches he's played this season, will face Thiemo de Bakker of the Netherlands in the first round. Djokovic could face tests from 2010 U.S. Open champion Juan Martin del Potro of Argentina or 6-foot-10 big server Ivo Karlovic of Croatia in the third round, and then No. 13 Richard Gasquet of France or No. 23 Thomaz Bellucci of Brazil in the fourth.

Djokovic lost the first set against Bellucci before coming back to win their semifinal at the Madrid Masters on clay this month.

Reigning Australian Open champion Djokovic and 16-time Grand Slam title winner Roger Federer were drawn to meet in the French Open semifinals. Nadal could meet No. 4 Andy Murray in the semifinals, while the Spaniard's quarterfinal opponent could be No. 5 Robin Soderling, the only man to beat him at Roland Garros.

Soderling was the runner-up in Paris each of the last two years, after upsetting Nadal in the fourth round in 2009, and Federer in the quarterfinals in 2010.

Federer's first opponent is Feliciano Lopez of Spain. While Federer has beaten Lopez all eight times they've met previously, their most recent match was close as can be: Federer won 7-6 (13), 6-7 (1), 7-6 (7) in Madrid.

Potential women's quarterfinals include No. 1 Caroline Wozniacki against 2010 runner-up Sam Stosur, four-time major champion Kim Clijsters against three-time major winner Maria Sharapova, No. 3 Vera Zvonareva against Schiavone, and No. 4 Victoria Azarenka against No. 6 Li Na.

Clijsters is at the French Open for the first time since 2006. Her first-round opponent is 100th-ranked Anastasiya Yakimova of Belarus. Wozniacki opens against 40-year-old Kimiko Date-Krumm of Japan.

According to the WTA, this is the first time in the Open era — which began in 1968 — that there are no American women seeded at the French Open.