New Delhi: In a new ray of hope for Alzheimer's patients, scientist here have now devised a bloodless technique to significantly help in early diagnosis of the debilitating condition and improve quality of life of those affected.

Dr Pravat K Mandal additional professor (Scientist V) at the National Brain Research Center and his team have used Magnetic Resonance Imaging (MRI) technique that can track an important component in the brain -- Glutathione (GSH)—that can indicate if a person stands the risk of suffering from Alzheimer's disease and thus help in early diagnosis by checking GSH level in selective brain region.

Glutathione acts like the brain cell's security guard and it decreases in Alzheimer's patients.

Not only this, "those undergoing treatment for Alzheimer's disease can be benefited by this study to test the efficacy of any medication by monitoring GSH level using this technique," Mandal said.

Alzheimer's disease is a brain disorder that impacts daily living through memory loss and cognitive changes. Symptoms of Alzheimer’s disease usually develop slowly and gradually worsen over time, progressing from mild forgetfulness to widespread brain impairment. As critical cells die, drastic personality loss occurs and body systems fail.

It affects millions of older adults and causes more worry for people over 55 years of age than any other condition.

Researchers at NBRC tried detecting GSH in various brain regions of healthy men and women in patients with mild cognitive impairment (MCI) and Alzheimer's disease. Mandal said, "We found that overall mean GSH content was found to be higher in healthy young females and males, especially more in females. GSH was distributed differently in two hemispheres among male and female subjects.

"In AD and MCI patients, we found a decrease in GSH levels. Statistical analysis indicated significant dearth of GSH in left frontal cortex region in female AD patients and right frontal cortex region in male AD patients."

This study was conducted amongst 85 participants.

Dr Manjari Tripathy with Department of Neurology, All India Institute of Medical Sciences had aided us with all patients of AD and MCI, he said.

This research is published in Biochemical and Biophysical Research Communications and also highlighted by Nature India.