Deaths due to overdose of prescription painkillers have risen sharply in recent years among women in the United States, a medical report said.

The US Centers for Disease Control and Prevention (CDC) said that between 1999 and 2010, the death toll from painkiller overdose increased more than 400 percent among American women, compared to 265 percent in American men. A total of 48,000 American women died due to painkiller overdose during the period, it said.

"Prescription painkiller deaths have skyrocketed in women," CDC director Tom Frieden said in a statement. "Stopping this epidemic in women, and men, is everyone's business. Doctors need to be cautious about prescribing and patients about using these drugs."

The study included emergency department visits and deaths related to drug misuse or abuse and overdose, as well as analyses specific to prescription painkillers.

It found that more than 6,600 American women died from prescription painkillers in 2010, which is four times the number that died from cocaine and heroin combined. The death rate was highest among women ages 45 to 54.