The proteins - p38 gamma and p38 delta - that control heart growth have been identified by researchers led by Guadalupe Sabio from the National Centre for Cardiovascular Research in Spain.
Sabio's group has found that p38 gamma and p38 delta regulate the growth of the left ventricle, the largest and strongest heart chamber, responsible for pumping oxygenated
blood to the body.
However, excessive physical exercise, hypertension, and obesity can trigger excessive heart growth (pathological hypertrophy), a situation that can lead to a heart attack.
The discovery advances understanding of the mechanisms through which heart cells grow and adapt.


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