According to sources, retromer plays a vital role in keeping amyloid precursor from being cleaved and producing the toxic byproduct amyloid beta or Abeta, which contributes to the development of Alzheimer’s.

Using computer-based virtual screening, the researchers identified a new class of compounds, called pharmacologic chaperones that can significantly increase retromer levels and decrease amyloid-beta levels in cultured hippocampal neurons, without apparent cell toxicity.

The challenge was to find small molecules-or pharmacologic chaperones-that could bind to retromer's weak point and stabilize the whole protein complex.

The compound called R55 was found to significantly increase the stability of retromer when the complex was subjected to heat stress.

The researchers then looked at how R55 affected neurons of the hippocampus, a key brain structure involved in learning and memory.


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