The molecule is a non-coding RNA which is named ‘Myheart’ by the researchers. It blocks a protein called BRG1 that interferes in usual genetic activities of the heart when it is in stress.

Scientists during the experiment restored levels of molecules in mice experiencing heart failure thus preventing the succession of the failure.

The scientists had earlier recorded that the protein which is crucial for the development of the heart in the foetus turns into a disruptor at later stages, especially when the heart undergoes stress due to high blood pressure.

The scientists discovered that during such periods of stress, it was noticed that production of Myheart is suppressed, leading to uncontrolled hara-kiri by BRG1.

In the new research, the researchers reported that in mice with stress-induced high levels of BRG1, they were able to restore Myheart to normal levels using gene transfer technology thus preventing heart failure in the process.

Dr Ching-Pin Chang, director of molecular and translational medicine, at the Krannert Institute of Cardiology said “I think of Myheart as a molecular crowbar that pries BRG1 off the genomic DNA and prevents it from manipulating genetic activity."

The team of researchers is trying to identify smaller areas of Myheart involved in the blocking activity as Myheart is too big a molecule to be delivered as a drug to humans.

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