The 17-time Grand Slam champion has won all the top titles in tennis during his stellar career with the exception of Olympic singles gold and the Davis Cup.
With good friend and Australian Open champion Stan Wawrinka at his side and with a modest Italian team in opposition, he may never have a better chance of achieving the latter.
Victory over Italy would put the Swiss into a November 21-23 final against either France or defending champions the Czech Republic who will contest the other semi-final in Paris.
Speaking after his loss to Marin Cilic in the US Open semi-finals last weekend, Federer left no doubt about where his focus was.
"Obviously I think we are the favourites, which is always a nice feeling to be. So 18,000 people in Switzerland is something very special.
"I think it's going to be record crowd for Swiss. I think people are quite excited to come see Stan and myself play, regardless of who it is against.
"Neighbouring country I think adds something special to it. I have had some memorable ties against Italians in the past. For me it was the first tie I ever played as a player in '99 against Davide Sanguinetti."
This time around the Italians will field 17th-ranked Fabio Fognini and 48th-ranked Andreas Seppi, neither of whom are thought likely to trouble world number three Federer and number four Wawrinka.
But the memory is still fresh from their quarter-final tie when the Swiss duo had to battle their way back from 2-1 down to Kazakhstan in order to reach the semis.
"We did not panic then and we will keep that in the back of our minds," said Wawrinka who was upset in four sets by Andrey Golubev in the opening rubber against the Kazakhs.

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