Mumbai: Amid unrest in the Middle East and a weakening Asian trend, Sensex opened 45 points lower on Wednesday. Foreign funds reduced their holdings in Indian blue-chip companies.

Bombay Stock Exchange benchmark’s the 30-share index dropped 44.79 points to 18,251.37 points in opening trade on Wednesday. The Sensex had fallen by 142.15 points on Tuesday.

In a similar fashion, the wide-based National Stock Exchange Nifty index moved down by 22.85 points to 5,446.35.

Brokers said sustained selling by funds and reports of a weakening trend on other Asian bourses, amid growing unrest in Libya, mainly influenced the trading sentiment.