The 30-share index was trading down by 125.30 points, or 0.45 percent, at 27,333.08 with stocks of metal, oil & gas, PSU, auto and banking sectors leading the fall.
The index had gained 549.56 points in the previous two sessions.
On similar lines, the National Stock Exchange Nifty shed 38.90 points, or 0.46 per cent, at 8,245.60.
Brokers said profit-booking by participants ahead of key economic data industrial production (IIP) numbers for November and inflation for December -- to be released later in the day, contributed to the fall.
Further, a weak trend at other Asian markets and weekend losses in US markets influenced trading sentiments here, they said.
Among other Asian markets, Hong Kong's Hang Seng was down 0.01 percent in morning trade, while Japan's financial markets will remain closed on Monday.
US Dow Jones Industrial Average ended 0.95 percent lower in Friday's trade.