Somdev, who had qualified for the singles main draw, battled hard for two hours 40 minutes before losing 6-7 (8), 4-6 5-7 to Italian 20th seed Andreas Seppi. (Agencies)
Bhupathi, partnering comeback girl Martina Hingis in the mixed doubles event, lost 6-7 (5) 6-7 (5) to Yung-Jan Chan and Robert Lindstedt in the first round.
Bhupathi has already exited from the men's doubles, so it is end of road for him at the last Grand Slam of the season, which is the last for the veteran Indian.
Bopanna had sweet-sour day as he advanced in the men's doubles but suffered a shock first round exit in the mixed doubles along with third seed German partner Julia Goerges.
Partnering Edourad Roger-Vasselin in the men's doubles, the sixth seed Indo-French team beat American pair of Bradley Klahn and Sam Querrey 6-2 6-4.
Bopanna joined Leander Paes and Divij Sharan in the men's doubles second round. They next clash with Russians Nikolay Davydenko and Mikhail Elgin.
However, disappointment was in store for Bopanna in the mixed doubles as he and Goerges, seeded third lost 7-6 (1) 2-6 6-10 to America's Abigail Spears and Santiago Gonzalez of Mexico. Also exiting from the mixed doubles was Sania Mirza.
The unseeded team of Sania and Romania's Horia Tecau suffered a 6-4 6-7 (10-12) 4-10 defeat at the hands of eight seeds Lizel Huber of America and Marcelo Melo of Brazil.
Somdev, who had qualified for the singles main draw, battled hard for two hours 40 minutes before losing 6-7 (8), 4-6 5-7 to Italian 20th seed Andreas Seppi.