"With diabetes, there is a tremendous need for oral delivery. People take insulin several times a day and delivery by needles is a big challenge," said professor Samir Mitragotri who specializes in targeted drug delivery.

For those who don't like needles, the discomfort injections can pose is a huge barrier to compliance, said Amrita Banerjee, a post-doctoral researcher in the Mitragotri Lab.

"It can lead to mismanagement of treatment and complications that lead to hospitalisation," she said.A pill, said the researchers, could circumvent the discomfort associated with the needle while potentially providing a more effective dose.

"When you deliver insulin by injection, it goes first through the peripheral bloodstream and then to blood circulation in the liver," Mitragotri explained."Oral delivery would take a more direct route, and, from a physiological point of view, a better one," he added.

While oral medications to assist the body with insulin production have been around for a while, a pill that delivers insulin remains a highly sought goal of diabetes medicine.

The new pill has demonstrated its ability to survive stomach acids with the protection of the enteric-coated capsule and deliver its payload to the small intestine.

The results were presented at the American Association of Pharmaceutical Scientists' annual meeting and exposition in Orlando, Florida.

 

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