Some 135 heads of state and government and dozens of ministers will attend the 71st General Assembly, the last for both Obama and U.N. Secretary-General Ban Ki-moon, who will step down at the end of 2016 after a decade in the job.

"While many conflicts are causing enormous pain, none is causing so much death, destruction and widespread instability as the worsening war in Syria," Ban told reporters on Wednesday. "Major countries with influence have a duty to use their influence and seize this latest opportunity to pursue a political solution."

Members of the International Syria Support Group (ISSG), which includes Russia and the United States, are likely to meet on the sidelines at the United Nations on Tuesday, diplomats said, while the U.N. Security Council is due to hold a high-level meeting on Syria on Wednesday. Russia had wanted the council to endorse its Syria truce deal with the United States during the meeting, but on Friday said a resolution was unlikely because Washington did not want to share the documents detailing the agreement with the 15-member body.

White House Deputy National Security Adviser Ben Rhodes said on Friday he anticipated many of the U.S. discussions at the United Nations "will focus on the situation in Syria, the response to North Korea's latest nuclear test, our shared efforts to combat (Islamic State) with many U.N. member states."

Nearly 5 million Syrians have fled the country, and some 6.5 million have been internally displaced during the more than five-year conflict, contributing to the record 65.3 million
people who were uprooted worldwide last year.

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