Van Persie, 30, did not travel with United on their pre-season tour of the United States, and will not appear in the final friendly against Valencia at Old Trafford on August 12, four days before their first league match.
Manager Louis van Gaal said his compatriot would resume training on Monday and, having missed much of last season through injury, would not be rushed back into the team before he reached full fitness.
"When a player has been on holiday for three weeks they have to train," Van Gaal was reported as saying by British media.
"I'm sorry but players have to train and Robin needs a full training regime behind him before he can play again. People can criticise me for my decision but I know what to do with players who have had three weeks' holiday,” he added.
"Hopefully, Robin will get his fitness back very fast but, for now, he won't play. Robin wants to play every game, I know that, but so do the other 30 players in the squad,” the Dutch coach said. 
Man United defenders impress new coach Van Gaal

Meanwhile, Manchester United defenders have impressed Van Gaal in their unbeaten pre-season tour with the Dutchman lauding the backline for adapting well to the new formation he has introduced since arriving at the club last month.
United defeated European champions Real Madrid 3-1 in the International Champions Cup match on Saturday to advance to Monday's final of the eight-team tournament against Liverpool in Miami.
The 20-times English champions have produced encouraging displays in the States, also beating Roma and Inter Milan, as they prepare for the start of the season under the 62-year-old coach.
United have played their tour matches with three centre backs and it will probably be the former Netherlands coach's preferred formation this season.
"It's amazing that they have picked up a new system like that, because it's not new for (Juan) Mata, for example - he plays in his position. Neither for (Wayne) Rooney, (Danny) Welbeck nor the two midfielders," Van Gaal said in the post-match press conference.
"The greatest impact with this new system is on the back line. But we only conceded one chance in the first half and two in the second."
Two first-half goals from Ashley Young and an 80th minute strike from substitute Javier Hernandez ensured United's victory in front of 109,318 people, the largest crowd to watch a football match in United States.
Real Madrid's only goal came in the 27th minute when Gareth Bale converted from the spot after he was fouled in the box by Michael Keane.
Van Gaal said Keane and fellow defender Tyler Blackett would grow better with experience.
"You saw them play today and they can do the job but not for a lot of matches - they can do it for one match. Maybe when you give them more matches, their experience shall increase,” Van Gaal said.
"But today the penalty was not so smart. He (Keane) has to learn from these errors. It's the same for Tyler - he can also play at this level but can he play match after match? That is the question and I cannot answer that at the moment,” he added.
Van Gaal said the victory will boost the confidence of the team, which finished a lowly seventh in the league last season and also missed out on qualification for the European tournaments under the then coach David Moyes.
"It's a very good result for us and it gives confidence to the players. I changed players in the second half but in spite of that, we scored again," he said.
"This wasn't a friendly - I had the feeling that Real Madrid didn't want to lose, which is why Ronaldo came on earlier than Carlo said (he would). But we won and deserved to win,” Van Gaal added.

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