The women with clinically significant depressive symptoms had even lower levels of klotho in their blood than those who were under stress but not experiencing such symptoms.


The study, published in Translational Psychiatry, is the first to show a link between psychological influences and klotho. "Our results suggest that klotho, which we now know is very important to health, could be a link between chronic stress and premature disease and death," said lead author Aric Prather, an assistant professor of psychiatry at University of California, San Francisco (UCSF).

Based on research in mice and worms, scientists know that when klotho is disrupted, it promotes symptoms of aging and when klotho is made more abundant, the animals live longer. The study included 90 high-stress caregivers and 88 low-stress controls, most of whom were in their 30s and 40s and otherwise healthy.

Klotho is known to decline with age, but in this cross-sectional study of relatively young women, this decline only happened among the high-stress women. The low-stress women did not show a significant reduction in klotho with aging.



Latest News from Lifestyle News Desk