Suarez will play some part in the match at the Bernabeu, his first competitive action since he sunk his teeth into Italy defender Giorgio Chiellini's shoulder at the World Cup finals in Brazil, Luis Enrique told a news conference.
"He will play some minutes," added the former Spain midfielder, who will preside over his first clasico since taking over as Barca coach at the end of last season.
"How many? That is the million dollar question. It is an important event for him and he will have some time on the pitch,” he said.
Suarez, who had already been sanctioned twice for biting opponents and once when he was accused of racially abusing Manchester United defender Patrice Evra, has been allowed to play friendlies and train with his new Barca team mates during his enforced absence.
The 27-year-old netted a double for Uruguay in this month's 3-0 friendly win over Oman, his second appearance for the South Americans on their tour of the Middle East after he featured in a 1-1 draw with Saudi Arabia.
Luis Enrique, who had stints at both Real and Barca as a player, said he was confident the referee would be able to control the players in a fixture that has often been marred by brawling and poor sportsmanship in recent years.
Barca would be attempting to play their customary possession game at the Bernabeu and avoid allowing their opponents chances to counter attack, he added.
"We intend to control the match," he told reporters.
"We need the ball and to make the fewest mistakes possible, as well as being efficient in attacking areas,” he added.
Barca top the La Liga standings on 22 points and have yet to concede a goal in eight matches this season.
After a stuttering start, Real have come into form in recent weeks and are four points behind their arch rivals in third, one adrift of second-placed Sevilla.   

Real have Ramos back for clasico but Bale sits it out
Meanwhile, Real Madrid will have their combative Spain centre back Sergio Ramos available for Saturday's "clasico" against Barcelona but Wales winger Gareth Bale is out, coach Carlo Ancelotti said on Friday.
Ramos, who has twice been sent off in recent clasicos, has shaken off a calf injury and should partner Pepe in the middle of defence after missing Wednesday's 3-0 Champions League victory at Liverpool, Ancelotti told a news conference previewing the game at Madrid's Bernabeu home.
However, Bale has not recovered sufficiently from a buttock muscle strain that also kept him out of the game at Anfield, the Italian added.
Real, after a wobbly start, have come into form in recent weeks and are four points behind their arch rivals in third, one adrift of Sevilla.
Barca's Uruguay forward Luis Suarez is set to make his official debut for the club as his four-month ban for biting an opponent at the World Cup in Brazil ends on Friday.
Messi, meanwhile, is one goal short of the La Liga scoring record of 251 goals set by former Athletic Bilbao striker Telmo Zarra six decades ago.
Ancelotti said Real would have to play a "perfect" game and team work would be crucial if they were to secure victory in the 169th Spanish top-flight meeting between the two European heavyweights. Real have won 70 to Barca's 66 with 32 draws.
"We have to do everything perfectly, attack perfectly and defend perfectly," Ancelotti told reporters.
"The key is that the players understand they have to put their quality at the service of the team,” he added.

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