Astronauts Rick Mastracchio and Steve Swanson are to embark on the 2.5 hour spacewalk beginning at 9:20 am (1320 GMT).
The computer they will remove and replace is known as a multiplexer/demultiplexer (MDM), one of 45 aboard the orbiting laboratory. The 10-year-old MDM failed after a routine restart operation on April 11.
NASA said the broken model provides commands to certain space station systems, including the external cooling system, solar alpha rotary joints and mobile transporter rail car. NASA television coverage will begin at 1230 GMT.
The spacewalk will mark the 179th in support of the orbiting space station, a global collaboration that includes Europe, Canada, Japan, the United States and Russia.
Just prior to the spacewalk, a Russian cargo capsule will undock from the space station for a two-day test of a new system to automatically reattach itself, NASA said. The Progress 53 resupply ship will separate from the space station at 4:58 am (0858 GMT), then retreat a distance of 500 kilometres.
"It will return back to the Zvezda docking port Friday morning after Russian flight controllers have tested its new Kurs automated rendezvous system," US space agency said. A similar operation was done in July 2012 when another Progress cargo freighter pulled away from the station and redocked, also for a trial run of its automated return system.


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