It was the third straight and sixth overall U.S. Open crown for the 32-year-old American, her 18 career slams putting her alongside Chris Evert and Martina Navratilova for fourth place on the all-time list.
Failing to get beyond the last 16 of the year's first three slams, Williams sailed through the U.S. Open without dropping a set, finishing off Dane Wozniacki in a snappy 75 minutes.
"I have been trying to reach it for so long, since last year," said Williams, hoisting her first grand slam trophy since lifting the same trophy a year ago. "I didn't really think I would get there. I just felt so good.
"I definitely did not think I was going to win a slam this year.
"To win the U.S. Open, that was my dream. Every time I win here it's just a really incredible special moment for me.
"I'm just a simple individual who just wants to win titles and wants to play tennis.
"The reason I play is to sit at the end of the day and hold the trophy or stand and hold the trophy. For me, that's my joy."
There was no joy, however, for Wozniacki.
Back in a grand slam final for the first time in five years, it was another frustrating end to a promising fortnight for the 10th seed as she once again left Flushing Meadows empty-handed, a major championship just beyond her grasp.
The title came with a massive pay-day for Williams, who pocketed the $3 million winner's purse along with a $1 million bonus for winning the U.S. Open Series of hard court tournaments that form the buildup to the year's last grand slam.
As Williams received her cheques she was joined on court by Navratilova and Evert, who presented her with an 18-carat gold Tiffany bracelet as the newest member of their grand slam club.
Margaret Court tops the list with 24 followed by Steffi Graf (22) and Helen Wills Moody (19).
"I just could never have imagined that I would be mentioned with Chris Evert or with Martina Navratilova, because I was just a kid with a dream and a racquet," said Williams. "Living in Compton, this never happened before.
"I just never could have imagined that it could have ended -- not ended. I'm just beginning."
The most difficult part of the match for Williams appeared to be beating a player she calls one of her best friends.
Williams and Wozniacki vacationed together this summer and the world number one said she exchanges text messages with the Dane daily.
But once the match began, Williams, who has often had to face off against her sister Venus, again proved there are no friendships on the court as she simply overpowered her 24-year-old opponent, firing 29 winners to just four by the Dane.
"When she's on her game it's not fun to play her," said Wozniacki, whose only other grand slam finals appearance also came at Flushing Meadows in 2009. "She's so strong. She has a good serve and she puts pressure on you straight away.
"When she needs to she can pull out that big serve. She has the power. She can push us back on the court and take the initiative, Wozniacki said.
"She definitely has the experience now, as well. I think that makes it even harder, because maybe back in the day she might have made not the right choices,” she said.
"Now she knows what she needs to do out there, and it makes it even harder to beat her," she added.

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