Scientists from the Spanish National Cancer Research Centre (CNIO), University of Valencia, and IMDEA Food from Madrid, tried to increase the global antioxidant capacity of the cells, rather than just one or a few antioxidant enzymes.
   
To achieve this, researchers have focused on increasing the levels of NADPH, a simple molecule that is important in antioxidant reactions.
   
The researchers used a genetic approach to increase NADPH levels. They generated transgenic mice with an increased glucose-6-phosphate dehydrogenase (G6PD) expression in their bodies, one of the important enzymes for production of NADPH.
   
The results show that an increase in G6PD and therefore in NADPH, increases the natural antioxidant defences of the organism, protecting it from oxidative damage, reducing ageing-related processes, such as insulin resistance, and increasing longevity.
   
When researchers analysed long-lived transgenic animals, they found that their levels of oxidative damage were lower than in non-transgenic animals of the same age.
   
They also studied the propensity of these animals to develop cancer and found no difference, suggesting that enhancing G6PD activity does not have an important effect on the development of cancer.
   
When researchers measured the ageing process in the transgenic mice, they found that the animals with a high G6PD expression and high levels of NADPH, delayed their ageing, metabolised sugar better and presented better movement coordination as they aged.
   
In addition, transgenic females lived 14 per cent longer than non-transgenic mice, while no significant effect on the longevity of males was observed.
   
"This increased longevity, although modest, is striking taking into account that until now attempts to increase longevity by manipulating individual antioxidant enzymes had failed," said Pablo Fernandez-Marcos, from IMDEA Food.

 

 

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Scientists from the Spanish National Cancer Research Centre (CNIO), University of Valencia, and IMDEA Food from Madrid, tried to increase the global antioxidant capacity of the cells, rather than just one or a few antioxidant enzymes.

To achieve this, researchers have focused on increasing the levels of NADPH, a simple molecule that is important in antioxidant reactions.

The researchers used a genetic approach to increase NADPH levels. They generated transgenic mice with an increased glucose-6-phosphate dehydrogenase (G6PD) expression in their bodies, one of the important enzymes for production of NADPH.

The results show that an increase in G6PD and therefore in NADPH, increases the natural antioxidant defences of the organism, protecting it from oxidative damage, reducing ageing-related processes, such as insulin resistance, and increasing longevity.

When researchers analysed long-lived transgenic animals, they found that their levels of oxidative damage were lower than in non-transgenic animals of the same age.

They also studied the propensity of these animals to develop cancer and found no difference, suggesting that enhancing G6PD activity does not have an important effect on the development of cancer.

When researchers measured the ageing process in the transgenic mice, they found that the animals with a high G6PD expression and high levels of NADPH, delayed their ageing, metabolised sugar better and presented better movement coordination as they aged.

In addition, transgenic females lived 14 per cent longer than non-transgenic mice, while no significant effect on the longevity of males was observed.

"This increased longevity, although modest, is striking taking into account that until now attempts to increase longevity by manipulating individual antioxidant enzymes had failed," said Pablo Fernandez-Marcos, from IMDEA Food.